Early high-frequency spinal cord stimulation treatment inhibited the activation of spinal mitogen-activated protein kinases and ameliorated spared nerve injury-induced neuropathic pain in rats

p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain

Shan‐Xue Jin, Zhi-Ye Zhuang, Clifford J. Woolf et al. · Journal of Neuroscience · 2003 · 861 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Novel 10-kHz High-frequency Therapy (HF10 Therapy) Is Superior to Traditional Low-frequency Spinal Cord Stimulation for the Treatment of Chronic Back and Leg Pain

Leonardo Kapural, Cong Yu, Matthew W. Doust et al. · Anesthesiology · 2015 · 829 citations · Full text

Medicine, Rehabilitation Medicine, Pain Management +11

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

Zhi‐Ye Zhuang, Peter Gerner, Clifford J. Woolf et al. · Pain · 2005 · 778 citations

Life Sciences, Neurobiology, Neuroscience +17

A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance

Zhi‐Ye Zhuang, Yeong‐Ray Wen, De-Ren Zhang et al. · Journal of Neuroscience · 2006 · 523 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Burst Spinal Cord Stimulation for Limb and Back Pain

Dirk De Ridder, Mark Plazier, Niels Kamerling et al. · World Neurosurgery · 2013 · 380 citations

Medicine, Neurology, Neurosurgery +14