Concepedia

Development of potent CPP6–gemcitabine conjugates against human prostate cancer cell line (PC-3)

Cristiana Correia, Cristina P. R. Xavier, Diana Duarte, Abigail Ferreira, Sara Moreira, M. Helena Vasconcelos, Nuno Vale

RSC Medicinal Chemistry · 2020 · 16 citations · 37 references

DOIFull text

Open access

Concepts

Abstract

Gemcitabine conjugation with CPP6 significantly enhanced cell growth inhibitory activity on PC-3 cells, with IC<sub>50</sub> between 14 and 15 nM.

References

37

Sulforhodamine B colorimetric assay for cytotoxicity screening

Vanicha Vichai, Kanyawim Kirtikara · Nature Protocols · 2006 · 3.7K citations

, , +8

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

José Baselga, Larry Norton, Joan Albanell et al. · PubMed · 1998 · 1K citations

, , +15

The Preference of Tryptophan for Membrane Interfaces

Wai‐Ming Yau, William C. Wimley, Klaus Gawrisch et al. · Biochemistry · 1998 · 916 citations · Full text

, , +17

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine.

Volker Heinemann, Yi-Zheng Xu, Sherri Chubb et al. · Molecular Pharmacology · 1990 · 407 citations

, , +13

Different Membrane Anchoring Positions of Tryptophan and Lysine in Synthetic Transmembrane α-Helical Peptides

Maurits R.R. de Planque, John A. W. Kruijtzer, Rob M. J. Liskamp et al. · Journal of Biological Chemistry · 1999 · 324 citations · Full text

, , +17