Concepedia

ASPM promotes glioblastoma growth by regulating G1 restriction point progression and Wnt-β-catenin signaling

Xin Chen, Lijie Huang, Yang Yang, Suhua Chen, Jianjun Sun, Changcheng Ma, Jingcheng Xie, Yongmei Song, Jun Yang

Aging · 2020 · 47 citations · 22 references

DOIFull text

Open access

Concepts

Abstract

. Furthermore, downregulation of ASPM could arrest the cell cycle of GBM cells at the G0/G1 phase and attenuate the Wnt/β-catenin signalling activity in GBM. These data suggest that ASPM may serve as a new target for the therapeutic treatment of GBM.

References

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Gene Ontology: tool for the unification of biology

Michael Ashburner, Catherine A. Ball, Judith A. Blake et al. · Nature Genetics · 2000 · 44.6K citations · Full text

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CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

Quinn T. Ostrom, Haley Gittleman, P Farah et al. · Neuro-Oncology · 2013 · 12.1K citations · Full text

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Exploration, normalization, and summaries of high density oligonucleotide array probe level data

Rafael A. Irizarry · Biostatistics · 2003 · 10.7K citations · Full text

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GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang, Chenwei Li, Chenwei Li et al. · Nucleic Acids Research · 2017 · 10.6K citations · Full text

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Roger Stupp, Monika E. Hegi, Warren Mason et al. · The Lancet Oncology · 2009 · 7.8K citations

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