Molecular Therapy — Nucleic Acids · 2020 · 94 citations · 34 references
MedicineCancer BiologyOncologyChemotherapyGene ExpressionMolecular OncologyCancer Stem CellsChemotherapy ResistanceNoncoding Rna In CancerPancreatic CancerSignal Transduction In CancerTumor Suppressor GenesAntioxidant Defense MechanismsCellular Antioxidant DefenseGemcitabine-based TherapyLong Non-coding Ribonucleic AcidsLong Non-coding Rna FunctionLong Noncoding Rna RegulationLong Noncoding Rna-mediated ResistanceNuclear Factor Erythroid 2-Related Factor 2 Signaling
-mediated ubiquitination and degradation of NRF2, leading to a low level of intracellular ROS, which is required for the maintenance of cancer stemness. These findings suggest SLC7A11-AS1 as a therapeutic target to overcome gemcitabine resistance for PDAC treatment.
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Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2019 · 21K citations · Full text
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
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Association of reactive oxygen species levels and radioresistance in cancer stem cells
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Medicine, Cancer Biology, Oncology +14
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature · 2011 · 2.2K citations · Full text