Isofraxidin Alleviates Myocardial Infarction Through NLRP3 Inflammasome Inhibition

The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction

Rifeng Gao, Huairui Shi, Suchi Chang et al. · International Immunopharmacology · 2019 · 163 citations

Inflammation, Heart Failure, Fibrosis +12

Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-α production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway

Xiaofeng Niu, Xing Wei, Weifeng Li et al. · International Immunopharmacology · 2012 · 89 citations

Inflammation, Cytokine, Anti-inflammatory +10

Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis

Yu Bian, Xin Li, Ping Pang et al. · Acta Pharmacologica Sinica · 2019 · 85 citations · Full text

Inflammation, Heart Failure, Anti-inflammatory +9

Isofraxidin, a Coumarin Component from Acanthopanax senticosus, Inhibits Matrix Metalloproteinase-7 Expression and Cell Invasion of Human Hepatoma Cells

Taisuke Yamazaki, Takayoshi Tokiwa · Biological and Pharmaceutical Bulletin · 2010 · 84 citations · Full text

Chemoprevention Strategy, Antiparasitic Agent, Pathology +21

Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis

Qiao Liao, Shuang Qu, Luxun Tang et al. · Acta Pharmacologica Sinica · 2019 · 80 citations · Full text

Angiogenesis, Therapeutic Effect, Cardiovascular Disease +8