Genome Medicine · 2019 · 493 citations · 5 references
MedicineBiomedical InformaticsHealth InformaticsDrug DiscoveryPrecision MedicineComputational Drug DiscoveryComputational Drug RepurposingDigital Twin DesignDigital TwinsPersonalized Drug ModelingPersonalized Therapy OptimizationSystems-level Drug Discovery
Personalized medicine requires the integration and processing of vast amounts of data. Here, we propose a solution to this challenge that is based on constructing Digital Twins. These are high-resolution models of individual patients that are computationally treated with thousands of drugs to find the drug that is optimal for the patient.
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