Concepedia

Musashi2 contributes to the maintenance of CD44v6+ liver cancer stem cells via notch1 signaling pathway

Xiju Wang, Ronghua Wang, Shuya Bai, Si Xiong, Yawen Li, Man Liu, Zhenxiong Zhao, Yun Wang, Yuchong Zhao, Wei Chen,

Journal of Experimental & Clinical Cancer Research · 2019 · 68 citations · 34 references

DOIFull text

Open access

Abstract

Our results demonstrated that MSI2 maintained the stemness of CD44v6+ LCSCs by activating Notch1 signaling through the interaction with LFNG, which could be a potential molecular target for stem cell-targeted therapy for liver cancer.

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