Concepedia

New pyrazole derivatives possessing amino/methanesulphonyl pharmacophore with good gastric safety profile: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory activity and histopathological studies

Khaled R.A. Abdellatif, Eman K. A. Abdelall, Phoebe F. Lamie, Madlen B. Labib, El-Shaymaa El-Nahaas, Marwa M. Abdelhakeem

Bioorganic Chemistry · 2019 · 51 citations · 19 references

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19

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

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The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

Jane L. Wang, David C. Limburg, Matthew J. Graneto et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 335 citations · Full text

, , +15

Cholinergic-mediated gastric mast cell degranulation with subsequent histamine H1- and H2-receptor activation in stress ulceration in rats

Chi H. Cho, Clive W. Ogle · European Journal of Pharmacology · 1979 · 165 citations

, , +17

Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II

Said El‐Feky, Z. K. ABD EL‐SAMII, Nermine A. Osman et al. · Bioorganic Chemistry · 2015 · 133 citations

, , +17

Design, Synthesis, and Biological Evaluation of 6-Substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones:  A Novel Class of Diarylheterocyclic Selective Cyclooxygenase-2 Inhibitors

Praveen P. N. Rao, Huiying Li, Amgad G. Habeeb et al. · Journal of Medicinal Chemistry · 2003 · 110 citations · Full text

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