<i>para</i>-Selective copper-catalyzed C(sp²)–H amidation/dimerization of anilides <i>via</i> a radical pathway

Abstract

)-H functionalization is achieved. The para-selective amidation is accomplished on the anilide aromatic ring via a radical pathway leading to C-N bond formation in the presence of ammonium persulfate as a radical source/oxidant for the copper catalyst. The developed protocol tolerates a wide range of anilide substrates. The regioselectivity is confirmed by single-crystal X-ray studies.