Concepedia

Intrathecal B-cell activation in LGI1 antibody encephalitis

Klaus Lehmann‐Horn, Sarosh R. Irani, Shengzhi Wang, Arumugam Palanichamy, Sarah Jahn, Ariele L. Greenfield, Ravi Dandekar, Gildas Lepennetier, Sophia Michael, Jeffrey M. Gelfand,

Neurology Neuroimmunology & Neuroinflammation · 2020 · 36 citations · 19 references

DOIFull text

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Abstract

Our results demonstrate that intrathecal immunoglobulin repertoire expansion is a feature of LGI1 antibody encephalitis and suggests a need for CNS-penetrant therapies.

References

19

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

Sarosh R. Irani, Sian K Alexander, Patrick Waters et al. · Brain · 2010 · 1.3K citations · Full text

Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis

Sarosh R. Irani, Andrew W. Michell, Bethan Lang et al. · Annals of Neurology · 2010 · 885 citations

Anti-LGI1 encephalitis

Agnes van Sonderen, Roland D. Thijs, Elias C. Coenders et al. · Neurology · 2016 · 612 citations

Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype

Sarosh R. Irani, Charlotte J. Stagg, Jonathan M. Schott et al. · Brain · 2013 · 420 citations

N‐methyl‐<scp>D</scp>‐aspartate receptor antibodies in herpes simplex encephalitis

Carsten Finke, Markus Höltje, Jörg Hofmann et al. · Annals of Neurology · 2012 · 402 citations