Concepedia

CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis

Chaohua Liu, Qiaoyan Yang, Qian Zhu, Xiaopeng Lu, Meiting Li, Tianyun Hou, Zhiming Li, Ming Tang, Yinglu Li, Hui Wang,

Theranostics · 2020 · 64 citations · 54 references

DOIFull text

Open access

Concepts

Abstract

: DOT1L acetylation by CBP drives CRC progression and metastasis. Targeting DOT1L deacetylation signaling is a potential therapeutic strategy for DOT1L-driven cancers.

References

54

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Combinatorial patterns of histone acetylations and methylations in the human genome

Zhibin Wang, Chongzhi Zang, Jeffrey Rosenfeld et al. · Nature Genetics · 2008 · 2.3K citations · Full text

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CBP/p300 in cell growth, transformation, and development

Richard H. Goodman, Sarah M. Smolik · Genes & Development · 2000 · 1.8K citations · Full text

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Colon Cancer Survival Rates With the New American Joint Committee on Cancer Sixth Edition Staging

J. B. O'Connell, Melinda A. Maggard, Clifford Y. Ko · JNCI Journal of the National Cancer Institute · 2004 · 1.6K citations · Full text

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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

Michael S.Y. Huen, Robert A. Grant, Isaac A. Manke et al. · Cell · 2007 · 1K citations · Full text

, , +16