<i>EGFR</i> Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma - Concepedia

Concepedia

Publication | Open Access

<i>EGFR</i> Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma

DOI Full Paper Access

45

Citations

43

References

2019

Year

Shaofang Wu, Feng Gao, Siyuan Zheng, Chen Zhang, Emmanuel Martínez-Ledesma, Ravesanker Ezhilarasan, Jie Ding, Xiaolong Li, Ningping Feng, Asha S. Multani,

Clinical Cancer Research

Abstract

<i>EGFR</i>-amplified cells are highly sensitive to talazoparib. Our data provide insight into the potential of using <i>EGFR</i> amplification as a selection biomarker for the development of personalized therapy.

References

	Year	Citations

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