Relationship of catalase activity distribution in serum and tissues of small experimental animals

Abstract

Abstract In the process of physiological activity of the body, a wide range of toxic metabolites is formed, in particular, hydrogen peroxide, superoxide and hydroxyl radical, which have a destructive effect on cells and cell membranes. One of the natural body protection mechanisms is the enzyme catalase, which accelerates the decomposition of constantly formed hydrogen peroxide to the final products, while oxidizing low molecular alcohols and nitrites, involved in the process of cellular respiration and does not require energy for activation. Catalase activity in blood and tissues is a marker of metabolic disorders. Catalase is localized mainly in the peroxisomes and cytoplasm of the cell, saturates the erythrocytes, liver and kidneys. Catalase activity allows assessing the level of endotoxicosis in the body. In order to study the relationship of the distribution of catalase concentration in serum and rat tissues, the following tasks were solved: the concentration of catalase in serum and tissues of the liver, brain, heart, as well as in skeletal muscle tissues of rats was determined; the correlation of catalase concentration distribution in blood serum and tissues of rat was revealed. The paper presents the results of nonparametric correlation analysis to assess the relationship of catalase activity distribution in serum and tissues of small experimental animals.