Adenosine Generated by Regulatory T Cells Induces CD8⁺T Cell Exhaustion in Gastric Cancer through A2aR Pathway

Abstract

The FoxP3⁺ Tregs and A2aR⁺/CD8⁺ T cells were excessively infiltrated in GC tissue. Tregs from GC can decompose ATP to adenosine and in turn induce apoptosis and inhibit the proliferation of CD8⁺ T cells through the A2aR pathway, further leading to immune escape of GC.