Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia–Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.2K citations

Inflammation, Signal Transduction, Signaling Pathway +12

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee et al. · Nature · 2015 · 3.5K citations

Inflammation, Anti-inflammatory, Signal Transduction +8

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding, Kun Wang, Wang Liu et al. · Nature · 2016 · 2.6K citations

Gasdermin Family, Protein Secretion, Biochemistry +2

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

Wanting He, Haoqiang Wan, Lichen Hu et al. · Cell Research · 2015 · 2.4K citations · Full text

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

Huayi Wang, Liming Sun, Lijing Su et al. · Molecular Cell · 2014 · 1.5K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +9