Jatrofolianes A and B: Two Highly Modified Lathyrane Diterpenoids from <i>Jatropha gossypiifolia</i>

Abstract

Jatrofolianes A (<b>1</b>) and B (<b>2</b>), which are two highly modified lathyrane diterpenoids, were isolated from <i>Jatropha gossypiifolia</i>. <b>1</b> incorporates an unusual transannular 1,3-dioxolane moiety, forming a unique 5/6/5/8/3 ring system, while <b>2</b> possesses a new 10,11:13,14-diseco-lathyrane skeleton with a 12-membered macrocyclic lactone ring. Their structures were determined by spectroscopic analysis, quantum chemical calculations, and single-crystal X-ray diffraction. <b>2</b> showed significant multidrug resistance (MDR) reversal activity to cancer cells HepG2/ADR and HCT-15/5-FU at 10 μM.