Visible-Light-Induced <i>para</i>-Selective C(sp²)–H Difluoroalkylation of Diverse (Hetero)aromatic Carbonyls

Abstract

An efficient visible-light-induced <i>para</i>-selective C(sp²)-H difluoroalkylation of diverse electron-deficient (hetero)aromatic carbonyls (aldehydes and ketones) at ambient temperature has been developed by employing Ir(ppy)₃ as the catalyst and 1,10-phenanthroline as the additive. This protocol was highlighted by its wide substrate scope, high regioselectivity, low catalyst usage, and operational simplicity.