Concepedia

Prevalence and prognostic role of PIK3CA E545K mutation in Iranian colorectal cancer patients.

Reza Ranjbar, Somayeh Mohammadpour, Amir Torshizi Esfahani, Sina Namazian, Mohammad Yaghob-Taleghani, Kaveh Baghaei, Seyed Abdolreza Mortazavi Tabatabaei, Leila Pasharavesh, Ehsan Nazemalhosseini Mojarad

PubMed · 2019 · 12 citations · 20 references

Full text

Open access

Abstract

A high frequency of PIK3CA E545K mutation was detected in Iranian CRC patients. The results of the present study suggested that PIK3CA E545K mutation may be associated with poor prognosis. These findings require further confirmation via prospective studies with larger samples.

References

20

Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

Reiki Nishimura, Tomofumi Osako, Yasuyuki Nishiyama et al. · Oncology · 2013 · 13.2K citations · Full text

Comprehensive molecular portraits of human breast tumours

Nature · 2012 · 12.1K citations · Full text

, , +6

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science · 2004 · 3.4K citations

, , +15

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

Wendy De Roock, Bart Claes, David Bernasconi et al. · The Lancet Oncology · 2010 · 2.1K citations

, , +5

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

Yardena Samuels, Luis A. Díaz, Oleg Schmidt‐Kittler et al. · Cancer Cell · 2005 · 909 citations · Full text

, , +13