Multiple Sclerosis Journal · 2019 · 37 citations · 7 references
Life SciencesNeurologyNeuroscienceClinical NeuroscienceCognitive NeuroscienceNeuropsychologyBrain ImagingCognitive ImpairmentMultiple SclerosisNeurodegenerative DiseasesNeurodegenerative DisordersThalamocortical SystemsCognitive PerformanceCognitive Performance ImpairmentCognitive Status AssessmentMultiple Sclerosis CognitionThalamic AnatomyThalamic LesionsThalamic PathologyThalamocortical Networks
BACKGROUND: The relationship between cognitive performance and regional thalamic atrophy in multiple sclerosis (MS) has been investigated in recent studies. OBJECTIVE AND METHODS: To further assess this relationship, 118 relapsing-remitting MS patients and 52 healthy controls underwent a neuropsychological assessment and a 3T-MRI (3-Tesla magnetic resonance imaging). Cognitive performances were correlated with thalamic shape changes by using Vertex Analysis. RESULTS: Information processing speed performance correlated with atrophy of frontal/motor-connected thalamic sub-regions. Inhibitory control performance correlated with atrophy of all thalamic sub-regions. Global cognitive status correlated with atrophy of frontal/temporal-connected sub-regions. CONCLUSIONS: These findings support the hypothesis that, within the thalamus, the damage of the anterior regions is most relevant for cognitive dysfunction.
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