Concepedia

Synthesis, cytotoxic evaluation, and molecular docking studies of novel quinazoline derivatives with benzenesulfonamide and anilide tails: Dual inhibitors of EGFR/HER2

Hamad M. Alkahtani, Ashraf N. Abdalla, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman A. Almehizia, Mashael G. Alanazi, Ahmed Y. Ahmed, Osama I. Alwassil, Hany W. Darwish, Alaa A.‐M. Abdel‐Aziz,

Bioorganic Chemistry · 2019 · 63 citations · 50 references

DOI

Concepts

References

50

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

D Li, Lauren Ambrogio, Takeshi Shimamura et al. · Oncogene · 2008 · 1.4K citations · Full text

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BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

PubMed · 2025 · 844 citations · Full text

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The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

David W. Rusnak, Karen Lackey, Karen Affleck et al. · PubMed · 2001 · 738 citations

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The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy

Zahi Mitri, Tina Constantine, Ruth O’Regan · Chemotherapy Research and Practice · 2012 · 517 citations · Full text

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Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study

Adel S. El‐Azab, Mohamed A. Al‐Omar, Alaa A.‐M. Abdel‐Aziz et al. · European Journal of Medicinal Chemistry · 2010 · 238 citations

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