Concepedia

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

Rebecca Mandt, María José Lafuente-Monasterio, Tomoyo Sakata‐Kato, Madeline R. Luth, Delfina C. Segura, Alba Pablos‐Tanarro, Sara Viera, Noemí Magán, Sabine Ottilie, Elizabeth A. Winzeler,

Science Translational Medicine · 2019 · 37 citations · 43 references

DOIFull text

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Concepts

Abstract

The malaria parasite Plasmodium falciparum readily develops resistance to dihydroorotate dehydrogenase inhibitors in vitro and in a mouse model of infection.

References

43

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