Concepedia

Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor

Nikolaos Georgakis, Elisavet Ioannou, Christina Varotsou, Georgios E. Premetis, Evangelia G. Chronopoulou, Nikolaos E. Labrou

Methods in molecular biology · 2019 · 13 citations · 5 references

DOI

Concepts

References

5

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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Guidelines for accurate EC50/IC50 estimation

Jeanne L. Sebaugh · Pharmaceutical Statistics · 2010 · 939 citations

, , +12

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

Regina Z. Cer, Uma Mudunuri, R. Scott Stephens et al. · Nucleic Acids Research · 2009 · 367 citations · Full text

, , +17

Hill coefficients, dose–response curves and allosteric mechanisms

Heino Prinz · Journal of Chemical Biology · 2009 · 295 citations · Full text

, , +16

An Intuitive Look at the Relationship of Ki and IC50: A More General Use for the Dixon Plot

Benjamin T. Burlingham, Theodore S. Widlanski · Journal of Chemical Education · 2003 · 263 citations

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