MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling

Abstract

This study provides compelling evidence about the critical role of miR-132 for the regeneration of mouse islet beta cells through the downregulation of its target Pten. Hence, the miR-132/Pten/Akt/Foxo3 signaling pathway may represent a suitable target to enhance beta cell mass.