4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ₁ Receptor Antagonists for the Treatment of Pain

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

Jonathan B. Baell, Georgina A. Holloway · Journal of Medicinal Chemistry · 2010 · 3.9K citations

Pharmacy, Biochemistry, Analytical Chemistry +14

Dimethyloxosulfonium Methylide ((CH₃)₂SOCH₂) and Dimethylsulfonium Methylide ((CH₃)₂SCH₂). Formation and Application to Organic Synthesis

E. J. Corey, Michael Chaykovsky · Journal of the American Chemical Society · 1965 · 1.6K citations

Natural Sciences, Chemistry, Inorganic Chemistry +4

Pain as a global public health priority

Daniel S. Goldberg, Summer McGee · BMC Public Health · 2011 · 1.4K citations · Full text

Public Affairs, Health Policy, Global Health +5

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

Kaoxiang Sun · Chinese New Drugs Journal · 2005 · 764 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 655 citations

Medicine, Medicinal Chemistry, Pharmacology +17