Orthodontic cell stress modifies proinflammatory cytokine expression in human PDL cells and induces immunomodulatory effects via TLR-4 signaling in vitro

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Life Sciences, Genetics, Immunology +15

Periodontal Ligament Cells Under Mechanical Stress Induce Osteoclastogenesis by Receptor Activator of Nuclear Factor κB Ligand Up-Regulation via Prostaglandin E2 Synthesis

Hiroyuki Kanzaki, Mirei Chiba, Yoshinobu Shimizu et al. · Journal of Bone and Mineral Research · 2002 · 529 citations

Life Sciences, Cell Biology, Oral Biology +17

Dysregulation of LPS-Induced Toll-Like Receptor 4-MyD88 Complex Formation and IL-1 Receptor-Associated Kinase 1 Activation in Endotoxin-Tolerant Cells

Andrei E. Medvedev, Arnd Lentschat, Larry M. Wahl et al. · The Journal of Immunology · 2002 · 272 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues

Pao‐Li Wang, Kiyoshi Ohura, Takeo Fujii et al. · Biochemical and Biophysical Research Communications · 2003 · 156 citations

Dentistry, Periodontics, Periodontology +14

Contrasting responses of human gingival and periodontal ligament fibroblasts to bacterial cell‐surface components through the CD14/Toll‐like receptor system

J. Hatakeyama, Riyoko Tamai, A. Sugiyama et al. · Oral Microbiology and Immunology · 2003 · 109 citations

Dentistry, Immunology, Oral Biology +14