Biomedicine & Pharmacotherapy · 2019 · 60 citations · 20 references
PharmacyMaterials ScienceOncologyBiomedical ImagingDrug DeliveryNanomaterialsInorganic NanoparticlesNanomedicineNanoparticle CharacterizationNanoparticle DesignProstate ImagingTumor ImagingManganese DistributionManganese-based Contrast AgentsNanoparticle Contrast AgentsNanoparticle Imaging AgentsNanoparticle-based Contrast AgentsNanoparticlesProstate-specific Membrane Antigen TargetingT1 Contrast
relaxivity. The targeted nanoparticles accumulated to a great extent in prostate cancer cells in vitro but not in noncancerous cells. In vivo studies further demonstrated a targeted distribution of PSA-Mn-Msn-Cy7 to cancer tissues as shown by high optical and T1 signals. The targeted distribution was also confirmed by determining the Mn content in the cancer tissues. Our data demonstrate that PSA targeted fluorescence and MR dual-functional nanoparticle can visualize prostate cancer and can be used as NIRF/MR contrast agents.
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