Angewandte Chemie International Edition · 2007 · 607 citations · 45 references
Natural SciencesOncologyRadiologyDiagnostic ImagingDiagnostic RadiologyNanomaterialsContrast AgentsInorganic NanoparticlesMagnetic NanomaterialsMagnetic Resonance Contrast MechanismsMagnetic Resonance ImagingMagnetic Resonance Imaging PhysicsMagnetic Resonance Imaging Contrast AgentsManganese Oxide NanomaterialsManganese-based Contrast AgentsNanoparticle Contrast AgentsNanoparticle Imaging AgentsNanoparticle Imaging ProbesNanoparticle-based Contrast AgentsNanoparticle-mediated Imaging
Contrasting images: A new T1 contrast agent for magnetic resonance imaging (MRI) based on MnO nanoparticles reveals a bright signal enhancement and fine anatomic structures in the T1-weighted MR image of a mouse brain (see picture; left MRI, right MnO-enhanced MRI (MONEMRI)). Furthermore, MnO nanoparticles conjugated with a tumor-specific antibody were used for selectively imaging breast cancer cells in a metastatic tumor in brain.
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