Harmless glucose‐modified ruthenium complexes suppressing cell migration of highly invasive cancer cell lines

Abstract

Glucose‐substituted ruthenium complexes [(η 6 ‐benzyl‐glucose)RuCp*] + Cl − , where Cp* = η 5 ‐C 5 Me 5 ; benzyl‐glucose = peracetylated benzyl β‐ d ‐glucopyranoside ( 1 ), benzyl β‐ d ‐glucopyranoside ( 2 ), have been prepared and used as efficient antimigration and anti‐invasive agents against metastatic breast cancer cells (MDA‐MB‐231) and cisplatin‐resistant ovarian cancer cells (SK‐OV‐3). In addition, these complexes were found to be essentially non‐toxic against non‐cancerous human kidney cells (HEK293).