Concepedia

Novel four-disulfide insulin analog with high aggregation stability and potency

Xiaochun Xiong, Alan Blakely, Prasoona Karra, Michael A. VandenBerg, Gabrielle Ghabash, Frank G. Whitby, Yi Wolf Zhang, Matthew J. Webber, William L. Holland, Christopher P. Hill,

Chemical Science · 2019 · 37 citations · 22 references

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Abstract

potency in mice compared to native insulin and demonstrates higher aggregation stability. In conclusion, we have discovered a novel four-disulfide insulin analog with high aggregation stability and potency.

References

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Extreme Stabilization of a Thermolysin-like Protease by an Engineered Disulfide Bond

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