Turkish Journal of Pharmaceutical Sciences · 2019 · 32 citations · 13 references
PharmacyPharmaceuticsPharmacokineticsDrug DeliveryNanoparticle Drug DeliveryPharmaceutical FormulationLipid-based Oral FormulationsNanomaterials For Drug DeliveryNanoparticle CharacterizationNanoparticle FormulationsOral NanocarriersSurfactantsControlled Drug ReleaseLipid NanoparticlesLipid-based Nanoparticle FormulationLow SolubilityNanoparticlesOral Drug BioavailabilityOral Nanoparticle BioavailabilityStability Of Lipid-based Formulations
OBJECTIVES: Azithromycin dihydrate is a macrolide antibiotic used for the treatment of several types of bacterial infections. The drug shows low oral bioavailability due to its low solubility. In the present work solid lipid nanoparticles of azithromycin dihydrate were formulated, keeping in view enhancement of the solubility and rate of dissolution of the drug. MATERIALS AND METHODS: drug release, and stability. RESULTS: release with a particle size suitable for lymphatic absorption. The nanoparticles formulated with poloxamer 188 showed better characteristics compared to the other surfactants. CONCLUSION: This study indicates that stearic acid nanoparticles of azithromycin dihydrate prepared by high shear homogenization can be successively used for improvement of dissolution and thereby oral bioavailability of the drug.
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