Local Anesthetics: Action, Metabolism, and Toxicity

A quantitative description of membrane current and its application to conduction and excitation in nerve

A. L. Hodgkin, A. F. Huxley · The Journal of Physiology · 1952 · 23.2K citations · Full text

Natural Sciences, Biophysics, Physiology +12

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

Bertil Hille · The Journal of General Physiology · 1977 · 1.8K citations · Full text

Medicine, Pharmacology, Anesthesia +16

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

Gary R. Strichartz · The Journal of General Physiology · 1973 · 665 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

Kenneth R. Courtney · Journal of Pharmacology and Experimental Therapeutics · 1975 · 394 citations

Medicine, Neurobiology, Pharmacology +17

Effect of Lidocaine on Ventricular Arrhythmias in Patients with Coronary Heart Disease

Ralph E. Gianelly, J. O. von der Groeben, Alfred P. Spivack et al. · New England Journal of Medicine · 1967 · 377 citations

Medicine, Cardiology, Pharmacology +17