Journal of Nanobiotechnology · 2019 · 31 citations · 20 references
MedicineOncologyPharmacologyCancer PharmacologyDrug DeliveryNanoparticle Drug DeliveryBiological MembranesBlood-brain Barrier BiologyBlood-brain Barrier DeliveryBlood-brain Barrier PenetrationBlood-brain Barrier PharmacologyLiposomal FormulationsBlood-brain Barrier PermeabilityBlood-tumor Barrier PenetrationCarrier-mediated Transport Across The Blood-brain BarrierCellular Uptake ModulationLiposome Delivery SystemsLiposome Surface ModificationLiposomesNanoparticle Cellular Uptake
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
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In vitro model for evaluating drug transport across the blood–brain barrier
R Cecchelli, B. Dehouck, Laurence Descamps et al. · Advanced Drug Delivery Reviews · 1999 · 403 citations