MicroRNA-32-5p knockout eliminates lipopolysaccharide-induced depressive-like behavior in mice through inhibition of astrocyte overactivity

Abstract

• miR-32-5p KO has no effect on the normal behavior and brain development of animals. • LPS enhanced expression of miR-32-5p, astrocytes and glutamate receptor. • miR-32-5p KO eliminates LPS-induced depression behavior. • miR-32-5p KO inhibits overactivation of astrocytes and glutamate receptor expression.