Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis

Cancer statistics, 2018

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2018 · 17K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Matthew J. Sanders, Pascal Grondin, Bronwyn D. Hegarty et al. · Biochemical Journal · 2007 · 668 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C<i>α</i> and native bovine protein phosphatase‐2A_c

Stephen Davies, Nicholas R. Helps, Philip Cohen et al. · FEBS Letters · 1995 · 602 citations

Life Sciences, Biochemistry, Molecular Biology +17

Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom).

Goro Chihara, Junji Hamuro, Yukiko Maeda et al. · PubMed · 1970 · 561 citations

Life Sciences, Oncology, Pharmacology +16

TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

Bo Wang, Shu‐Hao Hsu, Sarmila Majumder et al. · Oncogene · 2009 · 347 citations · Full text

Medicine, Molecular Biology, Oncology +14