Concepedia

The TOMMORROW study: Design of an Alzheimer's disease delay‐of‐onset clinical trial

Daniel K. Burns, Carl Chiang, Kathleen A. Welsh‐Bohmer, Stephen K. Brannan, Meredith Culp, Janet O’Neil, Grant Runyan, Patrick J. Harrigan, Brenda L. Plassman, Michael W. Lutz,

Alzheimer s & Dementia Translational Research & Clinical Interventions · 2019 · 41 citations · 37 references

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Abstract

The design of the TOMMORROW study addressed many key challenges to conducting a dual-objective phase 3 pivotal AD clinical trial in presymptomatic individuals. Experiences from planning and executing the TOMMORROW study may benefit future AD prevention/delay-of-onset trials.

References

37

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Guy M. McKhann, David S. Knopman, Howard Chertkow et al. · Alzheimer s & Dementia · 2011 · 18.4K citations · Full text

The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Marilyn S. Albert, Steven T. DeKosky, Dennis W. Dickson et al. · Alzheimer s & Dementia · 2011 · 9.9K citations

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Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Reisa A. Sperling, Paul Aisen, Laurel Beckett et al. · Alzheimer s & Dementia · 2011 · 7K citations · Full text

The Diagnosis of Mild Cognitive Impairment due to Alzheimer’s Disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease

Marilyn S. Albert, Steven T. DeKosky, Dennis W. Dickson et al. · FOCUS The Journal of Lifelong Learning in Psychiatry · 2013 · 2.6K citations

Estrogen Plus Progestin and the Incidence of Dementia and Mild Cognitive Impairment in Postmenopausal Women

Sally A. Shumaker, Claudine Legault, Stephen R. Rapp et al. · JAMA · 2003 · 2.2K citations