ACS Omega · 2019 · 11 citations · 48 references
3-Imino PyronesEnantioselective SynthesisEngineeringExclusive E-geometryOrganic ChemistryStereoselective SynthesisChemistryGlycine IminesHeterocycle ChemistrySynthetic Chemistryγ-Phosphonyl/sulfonyl CrotonatesBiomolecular EngineeringFunctionalized 2-Pyrones
A general method for highly functionalized 2-pyrones via a base-mediated sequential vinylogous addition and cyclization of γ-phosphonyl/sulfonyl crotonates and ynones are described. An exclusive E-geometry with respect to the newly generated olefin substituent at C3 of pyrone was observed. Imino glyoxalates and glycine imines similarly reacted with ynones to deliver 3-imino pyrones.
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Diels-Alder cycloadditions of 2-pyrones and 2-pyridones
Kamyar Afarinkia, V. Vinader, Todd D. Nelson et al. · Tetrahedron · 1992 · 338 citations · Full text
Heterocyclic, Organic Chemistry, Stereoselective Synthesis +3