New azo-azomethine derivative of sulfanilamide: Synthesis, Characterization, Spectroscopic, Antimicrobial and Antioxidant activity study

Abstract

Abstract A series of azo-azomethine compounds (Sb1- Sb5) have been synthesized with magnificent yield by condensation reaction of 4-((3-formyl-4-hydroxy-5-methoxyphenyl)diazenyl) enzenesulfonamide and aniline derivatives. The new azo compound was prepared from sulfanilamide by converting it to diazonium salt followed by coupling reaction with 2-hydroxy-3-methoxybenzaldehyde in alkaline medium. The structures of synthesized azo and azo-azomethine compounds have been established based on their spectral data (FT-IR, 1 HNMR, 13 CNMR)and elemental analysis (C,H,N).The purity of compound and evaluation of R f value were determined by TLC. The antimicrobial activity of azo-azomethine compounds have been tested in vitro against bacteria ( Staphylococcus aureus, Escherichia coli and Klepsilia pneumonia ) and fungi ( Candida glabrata, Candida albicane and Aspergillus niger ) by agar diffusion method, to assess their inhibiting potential. Also the antioxidant efficiency of azo-azomethine compounds have been calculated.