Atomic-level engineering and imaging of polypeptoid crystal lattices

Abstract

Significance A fundamental challenge in materials science is to understand the atomic-level structures of nanoarchitectures assembled from synthetic polymers. Here, we report a family of sequence-defined polypeptoids that form free-floating crystalline 2-dimensional nanosheets, in which not only individual polymer chains and their relative orientations, but also atoms in nanosheets were directly observed by cryogenic transmission electron microscopy. These atomic details are inaccessible by conventional scattering techniques. Using the feedback between sequence-controlled synthesis and atomic imaging, we observed how the nanosheet structure responds to chemical modifications at the atomic-length scale. These atomic-level insights open the door to the design of bioinspired nanomaterials with more precisely controlled structures and properties.