Ferrocene Amino Acid Ester Uracil Conjugates: Synthesis, Structure, Electrochemistry and Antimicrobial Evaluation

Abstract

Abstract Ferrocene‐amino acid ester‐uracil conjugates, derived from four amino acids ( l ‐alanine, glycine, β‐alanine and γ‐aminobutyric acid), were synthesized via the Cu(I)‐catalyzed azide‐alkyne cycloaddition as the key step. The new compounds were characterized spectroscopically and by single‐crystal X‐ray crystallography in the case of the derivatives of glycine (monoclinic, P 2 1 / c ) and γ‐aminobutyric acid (orthorhombic, Pca 2 1 ). Electrochemical measurements showed subtle influence of the compounds’ structure on the redox potential of the Fc/Fc + couple. Among the four compounds tested for antimicrobial activity, the conjugate obtained from l ‐alanine possessed weak antifungal activity against Candida guillermondii .