A De Novo Frameshift Mutation in TNFAIP3 Impairs A20 Deubiquitination Function to Cause Neuropsychiatric Systemic Lupus Erythematosus

Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Eric G. Lee, David L. Boone, Sophia Chai et al. · Science · 2000 · 1.4K citations · Full text

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

David L. Boone, Emre E. Turer, Eric G. Lee et al. · Nature Immunology · 2004 · 1.1K citations

Inflammation, Toll-like Receptors, Molecular Immunology +10

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Jianwen Han, Hou‐Feng Zheng, Yong Cui et al. · Nature Genetics · 2009 · 933 citations

Genome-wide Association Study, Disease Susceptibility, Autoimmune Disease +14

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

Qing Zhou, Hongying Wang, Daniella M. Schwartz et al. · Nature Genetics · 2015 · 601 citations · Full text

Inflammation, Rheumatology, A20 Haploinsufficiency Cause +14

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

Stacy L. Musone, Kimberly E. Taylor, Timothy T. Lu et al. · Nature Genetics · 2008 · 457 citations

Allelic Variant, Tnfaip3 Region, Autoimmune Disease +14