Concepedia

Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors

Jessica Lake, Andrew M. Donson, Eric Prince, Kurtis D. Davies, Anandani Nellan, Adam L. Green, Jean M. Mulcahy Levy, Kathleen Dorris, Rajeev Vibhakar, Todd C. Hankinson,

Pediatric Blood & Cancer · 2019 · 56 citations · 32 references

DOIFull text

Open access

Abstract

Fusion testing proved to be informative in a high percentage of cases. A large majority of fusion events in pediatric glial, glioneuronal, and ependymal tumors can be identified by relatively small gene panels.

References

32

Cancer statistics, 2019

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2019 · 20.7K citations · Full text

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Fast and SNP-tolerant detection of complex variants and splicing in short reads

Thomas D. Wu, Şerban Nacu · Bioinformatics · 2010 · 2K citations · Full text

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

Darcy A. Krueger, Marguerite M. Caré, Katherine Holland et al. · New England Journal of Medicine · 2010 · 990 citations · Full text

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Dominik Sturm, Brent A. Orr, Umut H. Toprak et al. · Cell · 2016 · 973 citations · Full text

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Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study

Theodore W. Laetsch, Steven G. DuBois, Leo Mascarenhas et al. · The Lancet Oncology · 2018 · 536 citations · Full text

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