Journal of Biological Chemistry · 2019 · 34 citations · 79 references
Life SciencesGeneticsMolecular BiologyChromatin BiologyEpigeneticsTranscriptional RegulationChromatinDevelopmental EpigeneticsDevelopmental EpigenomicsEpigenetic Control Of DifferentiationEpigenetic Regulation In DevelopmentHistone ModificationsHistone Demethylase InhibitionHistone DemethylasesHistone DemethylationHistone MethylationHistone-lysine Methylation
loci revealed a regulatory axis in which LSD1 induces demethylation of repressive histone H3 lysine 9 dimethylation (H3K9Me2) and interacts with transcription factor GATA2 to promote RNA polymerase II (RNA-POL-II) recruitment and activate gene transcription. Our study reveals a novel LSD1-GATA2 axis, which regulates human trophoblast syncytialization.
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