Concepedia

Publication | Open Access

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

DOIFull Paper Access

134

Citations

42

References

2019

Year

Takuto Chiba, Kevin Peasley, Kasey R. Cargill, Katherine Maringer, Sivakama S. Bharathi, Elina Mukherjee, Yuxun Zhang, Anja Holtz, Nathan Basisty, Shiva D. Yagobian,
Journal of the American Society of Nephrology

Abstract

Our findings indicate that Sirt5 regulates the balance of mitochondrial versus peroxisomal fatty acid oxidation in proximal tubular epithelial cells to protect against injury in AKI. This novel mechanism might be leveraged for developing AKI therapies.

References

YearCitations

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