Blautia genus associated with visceral fat accumulation in adults 20–76 years of age

Abstract

Abstract The gut microbiota is reported to be related to obesity, and visceral fat is reported to be strongly associated with cardiovascular disease and overall mortality. However, the association between the gut microbiota and obesity has mainly been studied using body mass index (BMI) as a proxy for obesity. We investigated the relationship of both visceral fat and BMI with the gut microbiota stratified by sex in a population-based cross-sectional study of Japanese men and women 20–76 years of age ( n = 1001). Women with a higher visceral fat area (VFA) harboured a higher relative abundance of the Firmicutes phylum ( P for trend <0.001) and a lower relative abundance of the Bacteroidetes phylum ( P for trend 0.030), whereas men with higher VFA harboured a lower relative abundance of the Firmicutes phylum ( P for trend 0.076) and a higher relative abundance of the Bacteroidetes phylum ( P for trend 0.013). Similar results were obtained using BMI as an index, but the differences were not significant in men. At the genus level, Blautia was the only gut microbe significantly and inversely associated with VFA regardless of sex. In conclusion, at the genus level we found that Blautia was the only gut microbe significantly and inversely associated with VFA, regardless of sex.