Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent <i>CCNE1</i> and <i>IGF2</i> enhancer hijacking in primary gastric adenocarcinoma

Abstract

Integrated paired-end NanoChIP-seq and WGS of gastric tumours reveals tumour-associated regulatory SV in regions associated with both simple and complex genomic rearrangements. Genomic rearrangements may thus exploit enhancer-hijacking as a common mechanism to drive oncogene expression in GC.