Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS

Abstract

Cognitive impairment as detected by the ECAS is a valid predictor of TDP-43 pathology in non-demented ALS. The profile of mild cognitive deficits specifically predicts regional cerebral involvement. These findings highlight the utility of the ECAS in accurately assessing the pathological burden of disease.