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Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells
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2019
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Epigenetic ChangeGeneticsDna MethylationHuman ObesityMetabolic RemodelingEpigeneticsOxidative StressObesityMetabolic SyndromeMetabolismGene ExpressionFunctional GenomicsCell BiologyChromatinMitochondrial FunctionEpigenomicsAdipose-derived Stem CellsMetabolic RegulationEpigenome-wide Association StudySystems BiologyMedicineMature Adipocytes
This epigenome-wide association study in stromal/stem cells (ASCs), derived from subcutaneous adipose tissue samples of lean and obese subjects, revealed a specific DNA methylation signature in adipocyte precursors associated with obesity, which has a significant impact on the metabolic phenotype and the mitochondrial function of mature adipocytes.