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A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate
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2019
Year
Progenitor CellsAdult Stem CellCell GrowthCell SpecializationOsteoporosisOrthopaedic SurgeryRadical SwitchRegenerative MedicineBone Morphogenic ProteinMurine Epiphyseal GrowthBone HomeostasisContinous DepletionStem CellsHealth SciencesCell DivisionMorphogenesisStem Cell NicheCell BiologyBiologyCell LineageDevelopmental BiologyClonality RevealsStem Cell ResearchCell Fate DeterminationMedicineEmbryonic Stem Cell
In brief: In this article, the authors present evidence that the murine epiphyseal growth plate develops a postnatal stem cell niche with monoclonal properties, that are able to self-renew. They thereby challenge the concept of a continous depletion of progenitor cells as a limiting factor for bone growth.