Concepedia

The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

So‐Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee‐Heun Kim, Ji‐Won Kim, Ji Young Kim, Jeong‐Seok Nam

Journal of Experimental & Clinical Cancer Research · 2019 · 302 citations · 35 references

DOIFull text

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Abstract

Herein, we first identified JAK2/STAT3/CCND2 signaling as a resistance mechanism for the persistent growth of CSCs after RT, suggesting potential biomarkers and regimens for improving outcomes among CRC patients.

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CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

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