Ratiometric two-photon fluorescent probe for <i>in situ</i> imaging of carboxylesterase (CE)-mediated mitochondrial acidification during medication

Abstract

We report on a dual ratiometric two-photon fluorescent probe for in situ sensing of mitochondrial CE activity and pH. Using the probe it is possible to visualize the CE-mediated acidification of hepatoma cells and hepatic tissues during medication with antipyretic anti-inflammatory drugs.